Thursday, June 6, 2013

Evernote finally remembers to add Reminders to Android app

Evernote updates Android app with Reminders feature

Two weeks after Evernote added Reminders to its Mac, iOS and web applications, the highly anticipated feature has arrived for Android as well. As with the other platforms, you can now set up an alarm just by tapping the clock icon in a note. You'll be able to configure due dates, times and whether you want to be alerted via an in-app notification or email. The Reminders are then attached to each notebook, allowing you to organize them in a to-do list if you so choose. You can permit friends or colleagues to subscribe to them too, which could be useful if you want note collaborators to keep track of project deadlines.

Aside from helping you memorize things, Evernote also added a few other improvements to the Android app. They include improved copy and paste in note view, corrected photo order in the multi-shot camera, more functional shortcuts and better Japanese language support. There's no need to remind yourself to download this update -- just head on over to the Google Play link and get it right now.

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Source: Google Play, Evernote

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/YGVYKBq8C8g/

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New screening technique paves the way for protein drugs from bacteria

June 5, 2013 ? A cheaper, more efficient technique for developing complex protein drugs from bacteria has been developed at the University of Sheffield.

Using the bacterium E. coli, researchers from the University's Faculty of Engineering showed it was possible to vastly increase the efficiency of the cells producing specifically modified proteins, as well as improve its performance and stability. The modification is present in over two-thirds of human therapeutic drugs on the market and involves the addition of specific sugar groups to the protein backbone, a process termed glycosylation.

Drugs based on proteins are increasingly important in modern medicine to tackle health problems including diabetes, cancer and arthritis.

Although simple proteins are traditionally made in microbial cells, these types of complex drugs are made using animal cells because they can make human-type glycosylations that will control its efficacy and stability in the body, and avoid immunogenic reactions in patients.

Using bacteria to make proteins for use as medicines could be a more cost effective alternative, since using animal cells is expensive. However, the efficiency of glycoprotein production in bacterial cells is still very poor, with yields often several thousand times lower than in animal cells.

Now, researchers in the Department of Chemical and Biological Engineering at the University of Sheffield, with collaboration from the University of Colorado, are using a technique called inverse metabolic engineering, that allows them to screen cells to identify strains that are likely to be the most efficient glycoprotein producers. Using this method, the team were able to produce seven times as much of the protein in laboratory tests.

The team then used mass spectrometry to characterise and accurately quantify the proteins being produced by the bacteria. This allowed them to pinpoint modifications that will enable them, ultimately, to improve the performance of the drug.

Professor Phil Wright, who led the research, said: "We believe that this technique will pave the way for pharmacologists to get the same protein yield from bacteria cells as they could from animal cells and also enable them to produce drugs from bacteria that have vastly improved focus and accuracy."

The team also tested the technique on antibody fragments with positive results, showing that their approach could work in different proteins.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/yRAe-uGCvjk/130605104428.htm

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Wednesday, June 5, 2013

Kerry says US, Venezuela on track to better ties

U.S. Secretary of State John Kerry lights a candle during his visit to San Francisco Church in Antigua Guatemala, Tuesday, June 4, 2013. Kerry is in Guatemala for the annual general assembly of the Organization of American States (OAS). (AP Photo/Moises Castillo)

U.S. Secretary of State John Kerry lights a candle during his visit to San Francisco Church in Antigua Guatemala, Tuesday, June 4, 2013. Kerry is in Guatemala for the annual general assembly of the Organization of American States (OAS). (AP Photo/Moises Castillo)

U.S. Secretary of State John Kerry receives a blessing from Priest Atilio Prandina during his visit to San Francisco Church in Antigua Guatemala, Tuesday, June 4, 2013. Kerry is in Guatemala for the annual general assembly of the Organization of American States (OAS). (AP Photo/Moises Castillo)

In this photo released by Guatemala's presidential press office, U.S. Secretary of State John Kerry, left, and Guatemala's President Otto Perez Molina shake hands during a meeting at the hotel Casa Santo Domingo in Antigua Guatemala, Tuesday, June 4, 2013. Kerry is in Guatemala for the annual general assembly of the Organization of American States (OAS). (AP Photo/Guatemala presidential press office)

U.S. Secretary of State John Kerry, center, visits the San Francisco Church in Antigua Guatemala, Tuesday, June 4, 2013. Kerry is in Guatemala for the annual general assembly of the Organization of American States (OAS). (AP Photo/Moises Castillo)

U.S. Secretary of State John Kerry, center, speaks with Vice Foreign Minister of Guatemala Rita Claverie, left, as U.S. ambassador to Guatemala Arnold Chacon walks with them as Kerry arrives to La Aurora air force base in Guatemala City, Tuesday, June 4, 2013. Kerry is in Guatemala for the annual general assembly of the Organization of American States (OAS). (AP Photo/Luis Soto)

(AP) ? The United States and Venezuela have agreed to begin a high-level dialogue with the aim of restoring ambassador-level relations and ending more than a decade of steadily deteriorating ties, U.S. Secretary of State John Kerry said Wednesday.

On his first trip to Latin America since taking office and after meeting Venezuela's foreign minister in the first cabinet-level discussion between the two nations in at least several years, Kerry said he was hopeful that a rapprochement could be achieved. The meeting, which came at Venezuela's request, took place just hours after Venezuela released from prison an American filmmaker who had been jailed on espionage charges, removing an immediate irritant in the relationship.

Kerry thanked Foreign Minister Elias Jose Jaua for the release of Timothy Tracy, calling it a "very positive development" and said he and his counterpart had spent about 40 minutes going over in detail areas in which the two countries could cooperate.

"We agreed today ? both of us, Venezuela and the United States ? that we would like to see our countries find a new way forward, establish a more constructive and positive relationship and find the ways to do that," he told reporters after the meeting. It took place in Guatemala on the sidelines of the annual Organization of American States general assembly.

"We agreed today there would an ongoing, continuing dialogue at a high-level between the State Department and the foreign ministry and we will try to set out an agenda on which we agree on things we can work on together," Kerry said.

He said the two countries aim to "begin to change the dialogue between our countries and hopefully quickly move to the appointment of ambassadors between our nations." That process, he said, could lead "ultimately to a series of steps that will indicate to the people of both countries as well as to the region that we're finding a way forward to a more constructive and understandable relationship."

The two countries haven't had ambassadors posted in each other's capitals since 2010 near the height of the estrangement between the U.S. and late populist Venezuelan President Hugo Chavez, who died in March.

The Obama administration has been eager to mend ties with Venezuela since the death of Chavez, who delighted in tweaking the United States and pursued policies that U.S. officials regarded as hostile. However, until Wednesday there had been little to show for the outreach.

In fact, U.S.-Venezuelan relations had been especially tense in recent months. Nicolas Maduro, a Chavez protege who claimed victory in the presidential election, expelled two U.S. military attaches in March the same day Chavez died, accusing them of trying to foment instability, and Tracy's arrest came amid domestic political turmoil over the election to replace Chavez.

In addition to being the first ministerial level meeting between the two nations since 2009, Wednesday's talks were the first significant contact between the two since the disputed April 14 election to replace Chavez. The opposition is still contesting the results.

Washington is willing to work with Maduro's new government but has said opposition questions about the electoral process must be addressed. The Obama administration has backed opposition candidate Henrique Capriles' call for a full recount.

But Kerry offered his thanks to Maduro, referring to him as president, after his meeting with the foreign minister.

"I want to thank the foreign minister, I want to thank President Maduro for taking the step to meet here on the sidelines of this conference," Kerry said. "I think it was a very important step."

U.S. officials have said despite the desire to move forward with a new chapter in ties with Venezuela, Washington would not stop expressing concerns about democracy and human rights in the country, particularly after the election.

Shortly before the two men were to meet, Venezuela released Tracy who had been jailed for what authorities said were attempts to destabilize the country.

President Barack Obama called that allegation "ridiculous." Family and friends say the 35-year-old Hollywood producer and actor had been making a documentary about Venezuelan politics when he was arrested on April 24 at the Caracas airport as he tried to leave the country to attend his father's 80th birthday in suburban Detroit.

Meanwhile, in a speech to the 35-member OAS annual general assembly, Kerry did not mention the developments with Venezuela, but reiterated U.S. concerns that some countries in the hemisphere are backsliding on their commitments to democracy and seeking to weaken OAS institutions that monitor and report on human rights.

"We must keep this organization's focus on its core objectives," Kerry said, calling for the OAS to redouble its efforts on protecting basic freedoms, improving rule of law and fighting corruption. "The Americas present a vivid example to the world that diversity is a strength, that inclusion works, that justice can overcome impunity, and that the rights of individuals must be protected against government overreach and abuse."

Kerry is pushing the candidacy of the US nominee for the Inter American Commission on Human Rights, James Cavallaro, a Stanford University law professor who is one of six people in the running for three spots on the panel that will be chosen later this week. Some OAS members are opposed to the U.S. having a presence on the commission because it is not also a member of the organization's human rights court.

"None of our countries is perfect, and we continue to draw strength from scrutiny and the opportunity to review our human rights practices," he said. "We are all diminished when we fail to defend the very institutions we created to safeguard the noble ideals (of) peace, democracy, development, liberty, and social justice based on respect for the essential rights of women and men."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-06-05-OAS-Kerry/id-8be70f68cc004992a593f3e63237c3ea

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Deenays Blog: Be Aware of Cancer;you yourself is your best physician


I have all the more reasons to be concerned to share knowledge of gynecologic cancer with my friends,especially female friends. My male friends should also pay attention to any complaint ,or rather enquire for, that their close ones,relatives or family members have. The following describes the symptoms of gynecologic cancer,which if detected early, shows good prognosis ( a forecasting of the probable course and outcome of a disease, especially of the chances of recovery.)

Gynecologic cancer can be of ovary,fallopian tube,uterus or the cervix. The average age of onset of uterine cancer is 60 years, ovarian cancer 63 , fallopian tube cancer 50-60 years,cervical 45-55 with the peak at 47 years of age. Of the various gynecologic cancers,uterine endometrial cancer has the highest survival rate.

Unfortunately,genetics and virus plays their roles in various cancers,including this one. Ones who have relatives who had gynecologic or breast cancer is in the high risk group,breast cancer being more related to ovarian cancer. Human Papiloma Virus (HPV) which is sexually transmitted causes mutation (alteration) of the genes,a major cause of Cervical cancer.

Symptoms of gynecologic cancer includes;

1. Swollen leg:
A painful swollen leg ,discharge or other cervical cancer symptoms.
2. Abnormal vaginal bleeding:
More than 90% of women diagnosed with endometrial cancer experience irregular bleeding e.g. bleeding between periods,heavy bleeding,bleeding after sex and menopausal bleeding.
3. Unexplained weight loss: Loss of more than 4.5 kg without any reason
4. Vaginal discharge colored with
blood:
Sometimes, it?s a sign of
cervical or endometrial cancer but mainly due to infection
5. Increased urge for urination : due to the pressure on the bladder (Uterus/womb lies above the bladder)
6. Appetite changes:
Appetite changes may be symptoms of
ovarian cancer.
7. Pelvic or abdominal pain:
Ongoing abdominal pain or discomfort ?
including gas, indigestion, pressure, bloating
and cramps ? can signal ovarian cancer. And,
constant pelvic pain or pressure can be a sign
of endometrial cancer.
8. Belly bloat:
A woman may have
ovarian cancer if she continues feeling bloated
for more than two weeks or after her period
ends.
9. Constant fatigue: which doesn't go away after rest
10. Persistent indigestion or nausea:
Occasionally, persistent indigestion or nausea
can signal gynecologic cancers

These symptoms however may be related to fibroid which is a benign condition,i.e. not cancerous. Gastrointestinal tuberculosis may also mask the diagnosis. If the symptoms persist for not less than two weeks,please consult a gynecologist, an oncologist or your general medicine doctor.

It is always better to prevent than try to cure a rather incurable disease. My dear young readers and friends,there is no need to be embarrassed. embarrassment does not cure diseases.

Cancer Centres in the North East
1. International Oncology Cancer
Clinic, Shija Hospitals and Research Institute,
Langol, Imphal West 795 004
Manipur

2. Dr B Borooah Cancer Institute
Gopinathnagar, Guwahati, Assam

3. Respective Departments of Hospitals

Source: http://koroumasek.blogspot.com/2013/06/be-aware-of-canceryou-yourself-is-your.html

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Meeting online leads to happier, more enduring marriages

June 3, 2013 ? More than a third of marriages between 2005 and 2012 began online, according to new research at the University of Chicago, which also found that online couples have happier, longer marriages.

Although the study did not determine why relationships that started online were more successful, the reasons may include the strong motivations of online daters, the availability of advance screening and the sheer volume of opportunities online.

"These data suggest that the Internet may be altering the dynamics and outcomes of marriage itself," said the study's lead author, John Cacioppo, the Tiffany and Margaret Blake Distinguished Service Professor in Psychology at the University of Chicago.

The results were published in the paper, "Marital Satisfaction and Breakups Differ Across Online and Offline Meeting Venues," in the current issue of the Proceedings of the National Academy of Sciences.? The survey was commissioned by eHarmony.com.*

Meeting online has become an increasingly common way to find a partner, with opportunities arising through social networks, exchanges of email, instant messages, multi-player games and virtual worlds, in which people "live" on the site through avatars. The research shows that couples who met online were more likely to have higher marital satisfaction and lower rates of marital breakups than relationships that began in face-to-face meetings.

Marriage breakups were reported in about 6 percent of the people who met online, compared with 7.6 percent of the people who met offline. Marriages for people who met online reported a mean score of 5.64 on a satisfaction survey, compared with a score of 5.48 for people who met offline. The survey was based on questions about their happiness with their marriage and degree of affection, communication and love for each other.

For the study, Cacioppo led a team that examined the results of a representative sample of 19,131 people who responded to a survey by Harris Interactive about their marriages and satisfaction.

The study found a wide variety of venues, both online and offline, where people met. About 45 percent met through an online dating site. People who met online were more likely to be older (30 to 39 is the largest age group represented); employed and had a higher income. The group was diverse racially and ethnically.

People who met offline found marriage partners at various venues including work, school, church, social gatherings, clubs and bars, and places of worship. Among the least successful marriages were those in which people met at bars, through blind dates and in online communities that function as virtual worlds, the researchers found.

Relationships that start online may benefit from selectivity and the focused nature of online dating, the authors said. The differences in marital outcomes from online and offline meetings persisted after controlling for demographic differences, but "it is possible that individuals who met their spouse online may be different in personality, motivation to form a long-term marital relationship, or some other factor," said Cacioppo.

Meeting online also may provide a larger pool of prospective marriage partners, along with advance screening in the case of dating services. And although deception often occurs online, studies suggest that people are relatively honest in online dating encounters; the lies tend to be minor misrepresentations of weight or height.

"Marital outcomes are influenced by a variety of factors. Where one meets their spouse is only one contributing factor, and the effects of where one meets one's spouse are understandably quite small and do not hold for everyone," Cacioppo said. "The results of this study are nevertheless encouraging, given the paradigm shift in terms of how Americans are meeting their spouses."

*The survey was commissioned by eHarmony.com and Cacioppo is paid as a scientific advisor for eHarmony. Joining him as authors in the study were Stephanie Cacioppo, a research associate and assistant professor in psychology at the University of Chicago; Gian Gonzaga, a researcher with Gestalt Research, who is a former director of the eHarmony Labs; and statisticians Elizabeth Ogburn, a research fellow in Harvard School of Public Health, and Tyler VanderWeele, a professor in epidemiology and biostatistics at Harvard. An agreement with eHarmony prior to data analysis ensured the company would not affect the publication of the study. To ensure integrity, the research team performed their study following procedures specified by JAMA, which included oversight by independent statisticians.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/82WQXuaQBYA/130603163751.htm

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Syria's chemical weapons program was built to counter Israel

By Anthony Deutsch and Khaled Yacoub Oweis

AMSTERDAM/AMMAN (Reuters) - Syria, defeated by Israel in three wars and afraid its arch enemy had gained a nuclear arsenal, began in earnest to build a covert chemical weapons program three decades ago, aided by its neighbors, allies and European chemical wholesalers.

Damascus lacked the technology and scientific capacity to set up a program on its own, but with backing from foreign allies it amassed what is believed to be one of the deadliest stockpiles of nerve agent in the world, Western military experts said.

"Syria was quite heavily reliant on outside help at the outset of its chemical weapons program, but the understanding now is that they have a domestic chemical weapons production capability," said Amy Smithson of the James Martin Center for Nonproliferation Studies in Washington, an expert on nuclear, biological and chemical weapons.

As Syria's civil war enters its third year with 80,000 dead, chemical weapons are reported to have been used by the government of President Bashar al-Assad, and there are also fears they could fall into the hands of militants seeking to destabilize the region.

As a result of the wars of 1967, 1973 and 1982, Syria sought to counter Israel's military superiority.

Non-conventional weapons have already been used in the region. The late Iraqi President Saddam Hussein used chemical weapons such as mustard gas and other nerve agents during the 1980s, including the killing of 5,000 Kurds in Halabja, during the war with Iran.

Syria's ally Iran is accused by the West of seeking to develop an atomic bomb, which it denies, while Israel refuses to confirm or deny whether it has nuclear weapons.

"Syria had to have something to stack up against Israel," Smithson told Reuters.

United Nations human rights investigators said on Tuesday they had "reasonable grounds" to believe that limited amounts of chemical weapons had been used in Syria. They had received allegations that government forces and rebels had used the banned weapons, but most testimony related to their use by the government.

Syria is one of only seven countries not to have joined the 1997 Chemical Weapons Convention, which commits members to completely destroying their stockpiles.

Syria does not generally comment on its chemical weapons, but in July last year it acknowledged for the first time that it had them. Foreign Ministry spokesman Jihad Makdissi told a news conference the army would not use chemical weapons to crush the rebels but could use them against foreign forces.

LOSING CONTROL

While it is relatively easy to produce small amounts of chemicals, scaling up to megaton quantities of precursors needed for weapons of mass destruction requires long-term, industrial-grade processing facilities with advanced equipment.

The first technology and delivery systems were most probably obtained from the Soviet Union and pre-revolution Egypt, military experts believe, while chemical precursors came from European companies.

To boost its own capabilities, Damascus set up the Scientific Studies and Research Centre (SSRC), an agency with a civilian figure head that was run by military intelligence.

It is "the best-equipped research center in Syria, possessing better technical capacity and equipment than the four Syrian universities," the Nuclear Threat Initiative, a leading non-proliferation group, wrote last month.

The SSRC, attacked by rebels earlier this year, oversees chemical weapons facilities in Dumayr, Khan Abou, Shamat, and Firaqlus, according to the U.S. Center for Strategic and International Studies. It set up facilities for blister agent, sarin, mustard and VX nerve gas, the Center said.

The agency is now headed by one of Assad's top advisers, national security chief Ali Mamlouk, said Brigadier General Mustafa al Sheikh, a Syrian army defector.

"The man overseeing the chemical weapons in general is Ali Mamlouk, but effective control of the weapons is becoming fragmented," Sheikh, who served for almost two decades in chemical weapons units, told Reuters from an undisclosed location in northern Syria. "Assad himself has lost overall command and control."

Mamlouk, on a list of Syrians targeted by EU sanctions since 2011, was promoted last year to head national security after its chief was killed in a bombing in Damascus. Considered to be a member of Assad's inner circle, Mamlouk is one of two Syrian officers indicted last August in Beirut for allegedly plotting to incite sectarian violence in Lebanon. Efforts to reach Mamlouk for comment were unsuccessful.

Sheikh said the arsenal is now in the hands of chemical weapons-trained loyalists of Assad's Alawite clan, a Shi'ite offshoot sect, and is being used for limited attacks that have killed dozens of rebels.

"Most of the chemical weapons have been transported to Alawite areas in Latakia and near the coast, where the regime has the capability to fire them using fairly accurate medium range surface-to-surface missiles," Sheikh said.

Some chemical munitions remain in bases around Damascus, and have been deployed with artillery shells. "It is a matter of time before fairly large warheads are used," he said.

A U.S. official, asked about Sheikh's comments, told Reuters: "This is one concerning scenario we're taking a close look at."

Reports of use of chemical weapons in the battlefield have become more frequent in recent weeks. A U.N. team of inspectors has been denied access and has been unable to verify the claims.

ILLEGAL SUPPLIERS

The bulk of chemical and biological weapons production technology came from "large chemical brokerage houses in Holland, Switzerland, France, Austria and Germany," said Globalsecurity, a security information provider.

In the early 1980s, Syria mostly imported French pharmaceuticals, some of them so-called "dual use" chemicals, which could also be used for chemical weapons, it said.

A wide range of industrial chemicals with legal applications, such as in agriculture, are also precursors for chemical weapons. The most important precursors for sarin, the nerve agent believed to have been used in recent fighting in Syria, are methylphosphonyl difluoride and isopropanol.

None of the reports cited named specific companies as suppliers. Syria has said it intended to use the chemicals for agriculture.

Securing raw chemicals on the international market became more difficult in 1985, when suspect sales were restricted by the Australia Group, a 40-nation body that seeks to curb chemical or biological weapons through export controls.

Some experts say Damascus obtained supplies from Russia and Iran instead, but Syria may also have turned to a network of illegal traders using front companies to sell to Iran and Iraq.

Former Russian general Anatoly Kuntsevich was suspected of smuggling precursor chemicals to VX gas to Syria, according to Globalsecurity. He died in 2002.

While questions remain about the origins of Syria's chemical weapons stockpile, an evaluation by the U.S. government in March leaves little doubt about the threat it poses.

"Syria's overall chemical weapons program is large, complex, and geographically dispersed, with sites for storage, production, and preparation," the Director of National Intelligence wrote.

It "has the potential to inflict mass casualties, and we assess that an increasingly beleaguered regime, having found its escalation of violence through conventional means inadequate, might be prepared to use chemical weapons against the Syrian people."

(Additional reporting by Phillip Stewart in Washington; Editing by Giles Elgood)

Source: http://news.yahoo.com/syrias-chemical-weapons-program-built-counter-israel-143645776.html

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Deadspin This Is The Face Of A Baseball Player Who Just Felt His Career End | Gizmodo The First Thin

Deadspin This Is The Face Of A Baseball Player Who Just Felt His Career End | Gizmodo The First Thing iOS 7 Needs to Steal from Android | Jalopnik Government Ship Launch Looks Badass But Goes Crazy Wrong | Lifehacker Six Communication Tricks That Will Get Your Kids to Cooperate

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